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Abstract #3649

Whole-Tumor Histogram Analysis of Monoexponential and Advanced Diffusion-weighted Imaging for Sinonasal Malignant Tumors: Correlations with Histopathologic Features

Zebin Xiao1, Zuohua Tang2, Jing Zhang3, Guang Yang3, Wenjiao Zeng4, Jianfeng Luo5, Rong Wang2, Linying Guo2, and Zhongshuai Zhang6

1Eye & ENT Hospital of Fudan University, Shanghai, China, 2Radiology, Eye & ENT Hospital of Fudan University, Shanghai, China, 3Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China, 4Pathology, School of Basic Medical Sciences, Fudan University, Shanghai, China, 5Biostatistics, School of Public Health, Fudan University, Shanghai, China, 6MR Scientific Marketing, Siemens Healthcare, Shanghai, China

This is the first study with a large sample size to systematically investigate the correlation of monoexponential diffusion-weighted imaging (DWI) and advanced DWI (intravoxel incoherent motion [IVIM] and diffusion kurtosis imaging [DKI]) parameters with histopathologic features of sinonasal malignant tumors using whole-tumor histogram analysis, which could improve the interpretation of DWI findings and promote the use of these diffusion methods in clinical practice. In comparison with monoexponential DWI and biexponential DWI (IVIM), histogram metrics derived from DKI may better reflect the microstructure of sinonasal malignant tumors, including the cellular, stromal and nuclear fractions.

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