Abstract #3653

How reproducible are the results of probabilistic white matter tract estimation?

Irène Brumer^1,2, Enrico De Vita¹, Jonathan Ashmore^2,3, Jozef Jarosz², and Marco Borri²

¹Department of Biomedical Egineering, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ²Department of Neuroradiology, King's College Hospital, London, United Kingdom, ³Department of Medical Physics and Bioengineering, NHS Highland, Inverness, United Kingdom

Diffusion tractography and fMRI data is valuable for pre-surgical planning, but its analysis involves a number of user-dependent decisions. In particular the choice of activation threshold in fMRI maps and the definition of seed region in tractography may impact the results. This work evaluates both the intrinsic variability of probabilistic white matter tract estimation and the inter-user reproducibility of tractography analysis. The former was estimated from repeated identical processing, while for the latter tracts obtained by different users were compared. Achieving a good inter-user reproducibility (up to 85%) is possible, considering that the intrinsic reproducibility ranged between 72% and 89%.

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