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Abstract #3653

How reproducible are the results of probabilistic white matter tract estimation?

Irène Brumer1,2, Enrico De Vita1, Jonathan Ashmore2,3, Jozef Jarosz2, and Marco Borri2

1Department of Biomedical Egineering, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2Department of Neuroradiology, King's College Hospital, London, United Kingdom, 3Department of Medical Physics and Bioengineering, NHS Highland, Inverness, United Kingdom

Diffusion tractography and fMRI data is valuable for pre-surgical planning, but its analysis involves a number of user-dependent decisions. In particular the choice of activation threshold in fMRI maps and the definition of seed region in tractography may impact the results. This work evaluates both the intrinsic variability of probabilistic white matter tract estimation and the inter-user reproducibility of tractography analysis. The former was estimated from repeated identical processing, while for the latter tracts obtained by different users were compared. Achieving a good inter-user reproducibility (up to 85%) is possible, considering that the intrinsic reproducibility ranged between 72% and 89%.

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