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Abstract #3676

Decreased Relative Cerebral Blood Flow In Unmedicated Heroin Use Disorders

Wenhan Yang1, Ru Yang1, Jing Luo1, Lei He1, Jun Liu1, and Jun Zhang2

1Department of Radiology, Second Xiangya Hospital of Central South University, Changsha, China, 2Department, Hunan Judicial Police Academy, Changsha, China

Sixty-eight patients with heroin use disorders(HUD) and forty-seven matched healthy controls underwent a high resolution T1 and whole-brain pulse arterial spin labeled (PASL) perfusion magnetic resonanceMRI scanning. We found that compared to control subjects, HUD showed worse neuropsychological performance and significantly decreased regional relative CBF ((rCBF)) in HUD patients had hypoperfusion in limbic, frontal, and temporol areas,and the correlation between middle frontal gyrus(MFG) and theneurocognitive measures.

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