Sixty-eight patients with heroin use disorders(HUD) and forty-seven matched healthy controls underwent a high resolution T1 and whole-brain pulse arterial spin labeled (PASL) perfusion magnetic resonanceMRI scanning. We found that compared to control subjects, HUD showed worse neuropsychological performance and significantly decreased regional relative CBF (（rCBF）) in HUD patients had hypoperfusion in limbic, frontal, and temporol areas,and the correlation between middle frontal gyrus(MFG) and theneurocognitive measures.
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