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Abstract #3699

Effects of Isoflurane on Brain Functional Connectivity in Common Marmosets

Naoki Kawaguchi1,2, Junichi Hata3, Yawara Haga3,4, Kanako Muta5, Koya Yachida1,3, Koshiro Terawaki1,2, Hirotaka James Okano2, Hideyuki Okano3, and Akira Furukawa4

1Department of Radiological Sciences, Faculty of Health Sciences, Tokyo Metropolitan University, Tokyo, Japan, 2Regenerative medicine, The Jikei University School of Medicine, Tokyo, Japan, 3Laboratory for Marmoset Neural Architecture, Center for Brain Science, RIKEN, Wako, Japan, 4Department of Radiological Sciences, Human Health Sciences, Tokyo Metropolitan University Graduate School, Tokyo, Japan, 5Veterinary Surgery Laboratory, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan

We examined the effects of isoflurane on brain functional connectivity in common marmosets using resting-state fMRI. We found that the thalamus was closely related to the mechanism of action of anesthesia and the default mode network (DMN), which is thought to function at rest. Isoflurane exhibited similar effect on the thalamus and human DMN region in humans but partly different effect onthe marmoset DMN region.In the future, we need to perform further investigations in detail by increasing the amount of data and reviewing analysis methods.

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