Meeting Banner
Abstract #3728

The Effect of End-tidal PETCO2 Clamping on Resting-state fMRI Connectivity

Ali M Golestani1 and J. Jean Chen2,3

1Department of Psychology, University of Toronto, Toronto, ON, Canada, 2Rotman Research Institute at Baycrest, Toronto, ON, Canada, 3Medical Biophysics, University of Toronto, Toronto, ON, Canada

The pressure of end-tidal CO2 (PETCO2) has a significant impact on the blood oxygenation level dependent (BOLD) signal and clamping it leads to detecting additional brain activation in task-based fMRI. However, the effect of PETCO2 clamping on the resting state connectivity has not been yet investigated. In this study we compared whole brain connectivity patterns of 13 healthy subjects during free-breathing and clamped PETCO2. Results showed clamping the PETCO2 removes the global and widespread effect of PETCO2 fluctuation in the gray matter, leading to weaker connectivity and more between-subject variability in the connectivity values.

This abstract and the presentation materials are available to members only; a login is required.

Join Here