Abstract #3728

The Effect of End-tidal PETCO2 Clamping on Resting-state fMRI Connectivity

Ali M Golestani¹ and J. Jean Chen^2,3

¹Department of Psychology, University of Toronto, Toronto, ON, Canada, ²Rotman Research Institute at Baycrest, Toronto, ON, Canada, ³Medical Biophysics, University of Toronto, Toronto, ON, Canada

The pressure of end-tidal CO₂ (PETCO₂) has a significant impact on the blood oxygenation level dependent (BOLD) signal and clamping it leads to detecting additional brain activation in task-based fMRI. However, the effect of PETCO₂ clamping on the resting state connectivity has not been yet investigated. In this study we compared whole brain connectivity patterns of 13 healthy subjects during free-breathing and clamped PETCO₂. Results showed clamping the PETCO₂ removes the global and widespread effect of PETCO₂ fluctuation in the gray matter, leading to weaker connectivity and more between-subject variability in the connectivity values.

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