Abstract #3739

Connectivity in the Default Mode Network of Schizophrenic Patients Investigated with Microstates and mGluR5 Receptor Availability Using Simultaneously Recorded Trimodal ([11C]ABP688-PET/MR/EEG) Imaging

Ravichandran Rajkumar^1,2,3, Claudia Régio Brambilla^1,2,3, Joshua Bierbrier^1,4, Shukti Ramkiran^1,2, Linda Orth^1,2, Andrej Ruch², Andreas Matusch⁵, Markus Lang⁶, Lutz Tellmann¹, Ezequiel Farrher¹, Jörg Mauler¹, Elena Rota Kops¹, Jürgen Scheins¹, Bernd Neumaier⁶, Johannes Ermert⁶, Hans Herzog¹, Karl-Josef Langen^1,3,7, Christoph Lerche¹, N. Jon Shah^1,3,8,9, and Irene Neuner^1,2,3

¹Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany, ²Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany, ³JARA - BRAIN - Translational Medicine, Jülich, Aachen, Germany, ⁴Department of Electrical and Computer Engineering, McMaster University, Hamilton, ON, Canada, ⁵Institute of Neuroscience and Medicine 2, INM-2, Forschungszentrum Jülich, Jülich, Germany, ⁶Institute of Neuroscience and Medicine 5, INM-5, Forschungszentrum Jülich, Jülich, Germany, ⁷Department of Nuclear Medicine, RWTH Aachen University, Aachen, Germany, ⁸Institute of Neuroscience and Medicine 11, INM-11, Forschungszentrum Jülich, Jülich, Germany, ⁹Department of Neurology, RWTH Aachen University, Aachen, Germany

This exploratory study aims at underpinning the relationship between functional connectivity (fMRI), microstates (EEG) and glutamatergic receptor (mGluR5) availability ([¹¹C]ABP688-PET) in healthy controls (HC) and schizophrenic (SZ) patients using simultaneously acquired trimodal (PET/MR/EEG) data. The single modality results show hyperactivity in vDMN regions of SZ patients (fMRI), a significant decrease in volume of distribution (V_t) of SZ patients (non-smoker group), and increased microstate global field power (GFP) in SZ patients. Correlations between V_t and GFP did not reveal any significant results, but the trend suggests a strong influence of smoking status and its association with global reductions in mGluR5 availability.

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