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Abstract #3739

Connectivity in the Default Mode Network of Schizophrenic Patients Investigated with Microstates and mGluR5 Receptor Availability Using Simultaneously Recorded Trimodal ([11C]ABP688-PET/MR/EEG) Imaging

Ravichandran Rajkumar1,2,3, Claudia Régio Brambilla1,2,3, Joshua Bierbrier1,4, Shukti Ramkiran1,2, Linda Orth1,2, Andrej Ruch2, Andreas Matusch5, Markus Lang6, Lutz Tellmann1, Ezequiel Farrher1, Jörg Mauler1, Elena Rota Kops1, Jürgen Scheins1, Bernd Neumaier6, Johannes Ermert6, Hans Herzog1, Karl-Josef Langen1,3,7, Christoph Lerche1, N. Jon Shah1,3,8,9, and Irene Neuner1,2,3

1Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany, 2Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany, 3JARA - BRAIN - Translational Medicine, Jülich, Aachen, Germany, 4Department of Electrical and Computer Engineering, McMaster University, Hamilton, ON, Canada, 5Institute of Neuroscience and Medicine 2, INM-2, Forschungszentrum Jülich, Jülich, Germany, 6Institute of Neuroscience and Medicine 5, INM-5, Forschungszentrum Jülich, Jülich, Germany, 7Department of Nuclear Medicine, RWTH Aachen University, Aachen, Germany, 8Institute of Neuroscience and Medicine 11, INM-11, Forschungszentrum Jülich, Jülich, Germany, 9Department of Neurology, RWTH Aachen University, Aachen, Germany

This exploratory study aims at underpinning the relationship between functional connectivity (fMRI), microstates (EEG) and glutamatergic receptor (mGluR5) availability ([11C]ABP688-PET) in healthy controls (HC) and schizophrenic (SZ) patients using simultaneously acquired trimodal (PET/MR/EEG) data. The single modality results show hyperactivity in vDMN regions of SZ patients (fMRI), a significant decrease in volume of distribution (Vt) of SZ patients (non-smoker group), and increased microstate global field power (GFP) in SZ patients. Correlations between Vt and GFP did not reveal any significant results, but the trend suggests a strong influence of smoking status and its association with global reductions in mGluR5 availability.

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