Abstract #3750

Line Scanning fMRI combined with optical calcium recordings to resolve the direct BOLD response to underlying slow oscillation-associated traveling waves

Dirk Cleppien¹, Felipe Aedo-Jury¹, Miriam Schwalm¹, Nuse Afahaene¹, and Albrecht Stroh¹

¹AG Molecular Imaging and Optogenetics of the Institute of Pathophysiology, University Medical School of Johannes Gutenberg-University Mainz, Mainz, Germany

In this multimodal approach consisting of line scanning (ls)-fMRI combined with optical calcium recordings, we investigated the direct BOLD response on a sensory stimulus in the slow wave brain state in anesthetized rats. We were able to observe the fMRI correlate of a slow wave recruiting the field of view with a significant latency between the recruitment of posterior and anterior voxels. This latency suggest the identification of the propagation of slow waves, as described with optical methods.

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