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Abstract #3757

Improved Selection of Hemodynamic Response Function in ASL Based Perfusion fMRI

Qingfei Luo1, Wen-Ming Luh2, and Jerzy Bodurka1,3

1Laureate Institute for Brain Research, Tulsa, OK, United States, 2Cornell MRI Facility, Cornell University, Ithaca, NY, United States, 3Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, United States

Two types of hemodynamic response function (HRF) are used in the data analysis of ASL based perfusion fMRI (ASL-fMRI): single gamma function (1-gamma) and the sum of two gamma functions (2-gamma). This study aims to optimize the selection of HRF by comparing the performances of standard 1-gamma and 2-gamma HRFs and also a modified 2-gamma HRF, which has earlier response peak time than the standard one. Our visual ASL-fMRI experiment indicate that the modified 2-gamma provides the best detection sensitivity and we recommend to use it in ASL-fMRI.

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