Effects of Spinal Cord vascular geometry on the BOLD-fMRI contrast
Fabio Mangini1, Laura Maugeri1, Mauro DiNuzzo1, Marta Moraschi2, Daniele Mascali2, Alejandra Sierra3, Alessia Cedola4, Federico Giove2, and Michela Fratini1
1IRCCS Fondazione Santa Lucia, Rome, Italy, 2Centro Fermi-Museo Storico della Fisica e Centro Studi e Ricerche "Enrico Fermi", Rome, Italy, 3A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, 4CNR-Nanontec, c/o Dipartimento di Fisica, Rome, Italy
The effects of the spinal cord (SC) vessel topology on the blood oxygenation level dependent (BOLD) signal is poorly characterized. We performed numerical simulations on models of vasculature systems based on the vascular network extracted from X ray tomographic images of a mouse SC. By taking into account the different vessels orientation of the SC, our results provides useful information to understand how the vascular distribution influences the BOLD contrast.
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