Abstract #3769

Effects of Spinal Cord vascular geometry on the BOLD-fMRI contrast

Fabio Mangini¹, Laura Maugeri¹, Mauro DiNuzzo¹, Marta Moraschi², Daniele Mascali², Alejandra Sierra³, Alessia Cedola⁴, Federico Giove², and Michela Fratini¹

¹IRCCS Fondazione Santa Lucia, Rome, Italy, ²Centro Fermi-Museo Storico della Fisica e Centro Studi e Ricerche "Enrico Fermi", Rome, Italy, ³A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, ⁴CNR-Nanontec, c/o Dipartimento di Fisica, Rome, Italy

The effects of the spinal cord (SC) vessel topology on the blood oxygenation level dependent (BOLD) signal is poorly characterized. We performed numerical simulations on models of vasculature systems based on the vascular network extracted from X ray tomographic images of a mouse SC. By taking into account the different vessels orientation of the SC, our results provides useful information to understand how the vascular distribution influences the BOLD contrast.

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