The vascular space occupancy (VASO) fMRI method probes changes in cerebral blood volume (CBV) but subsequent BOLD response contaminates the VASO signal reducing its SNR. Quantifying this BOLD contamination for different pulse-sequence parameters would improve our ability to measure CBV changes and optimize their quantification in a variety of physiological states and diseases. We have implemented a Monte Carlo method to model such effect from experimental cortical angiograms measured with two-photon microscopy on mice brains. Our results indicate that at 3T the BOLD contamination is relatively low (below 10%) but that this contamination is much higher at 7T and above.
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