Patients with Parkinson's disease (PD) are more likely to suffer cognitive decline and experience difficulties in daily living requiring reasoning including medication use, financial management, and nutrition and food preparation even at early stage of the disease.1,2 The present study aimed to explore L-dopa modulation on the reasoning ability in PD. Twenty non-demented PD underwent reasoning fMRI examinations OFF-medication and ON-medication. It was found that ON-medication PD patients exhibited improved reasoning performance and recruited the striatum compared to OFF-medication. The current findings suggest that L-dopa treatment mediated the neural activity in the striatum and further improved the behavior performance.
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