Abstract #3808

Longitudinal assessment of Focused ultrasound (FUS) induced Blood-Brain Barrier (BBB) opening in the non-human primate under 7T MRI

Kaiyue Wang^1,2 and Chih-Hung Chai³

¹Interdisciplinary Institute of Neuroscience and Technology (ZIINT), Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, China, Hangzhou, China, ²College of Biomedical Engineering & Instrument Science，Zhejiang University, Hangzhou, China, Hangzhou, China, ³School of Medicine, Department of Electrical Engineering, Chang Gung University, Taoyuan, Taiwan, Taiwan, China

Microbubble-mediated focused ultrasound can noninvasively induce reversible blood-brain barrier (BBB) opening in both rodents and non-human primates. However, it remains unclear whether FUS-induced BBB opening is accompanied by neuromodulation. Here we longitudinally characterized the duration and the functional effects of FUS-induced BBB opening by measuring changes in contrast-enhanced T1-weighted images (T1-WIs) and blood-oxygen-level dependent (BOLD) responses, respectively. The results show that BBB recovered at 6.5h post-FUS exposure. The blood-oxygen-level dependent (BOLD) changes during the visual stimulus pre- and post- FUS exposure didn't show similar change trend in both hemispheres. The results of fMRI-guided FUS may contribute to the development of FUS-induced BBB opening for clinical applications.

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