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Abstract #3810

Enhancement of the HIFU thermal effect in ex-vivo kidneys using a new class of endovascular sono-sensitizers

Orane Lorton1, Pauline Guillemin1, Romain Breguet2, Stéphane Desgranges3, Laura Gui1, François Lazeyras4, Antonio Nastasi5, Lindsey A. Crowe2, Nicolas Taulier6, Christiane Contino-Pépin3, and Rares Salomir1,2

1Image Guided Interventions Laboratory, Faculty of Medicine, University of Geneva, Geneva, Switzerland, Geneva, Switzerland, 2Radiology Department, University Hospitals of Geneva, Geneva, Switzerland, Geneva, Switzerland, 3University of Avignon, CBSA-IBMM (UMR5247), Avignon, France, Avignon, Switzerland, 4Department of Radiology and Medical Informatics, University of Geneva, Switzerland, Geneva, Switzerland, 5Research and Development Laboratory, Visceral and Transplantation Service, University Hospital Geneva, Geneva, Switzerland., Geneva, Switzerland, 6Sorbonne Universités, UPMC Univ Paris 06, CNRS, INSERM, Laboratoire d’Imagerie Biomédicale (LIB), F-75006, Paris, France, Paris, Switzerland

Magnetic Resonance guided High Intensity Focused Ultrasound (MRgHIFU) is a promising approach for the non-invasive ablation of localized tumors. Ablation of highly perfused tumors is challenging due to the heat sink effect. We developed a new concept of endovascular liquid core micro-droplets, used as sono-sensitizers for the enhanced absorption of the HIFU beam. We demonstrated the improvement of the HIFU thermal effect after adjunction of sono-activable micro-droplets in the perfusion fluid of freshly excised viable pig kidneys. Temperature maps were computed using the PRFS method to prove the enhancement of thermal contrast.

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