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Abstract #3838

Ten Minutes for the Brain to Settle: an In-vivo Investigation of Positional Brain Shift

Stefano Zappala1, Nicholas Bennion2, Slawomir Kusmia3, Jing Wu1, Sam Evans2, Derek Jones3, and David Marshall1

1Computer Science and Informatics, Cardiff University, Cardiff, United Kingdom, 2School of Engineering, Cardiff University, Cardiff, United Kingdom, 3Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, United Kingdom

Positional brain shift (BS), as the physiological sagging of the brain under the effect of gravity, has a magnitude that is comparable to the accuracy of neuronavigational systems. It is a complex interaction of gravity, anatomical boundaries and tissue mesostructure. A comprehensive investigation of such deformation is needed. This study aims to provide a rich set of volumetric measures to infer the pattern of deformation as well as the time evolution of positional BS. Results show that positional BS is a relatively fast process, stabilised in 10 minutes, with local variations strongly dependent on the variability of anatomical structures between different subjects.

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