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Abstract #3849

MINIMA – Minimally invasive, image guided ablation using MRI

Chris Payne1, Rebecca Baker1, Matin J Mohseni1, John J Connell1, Peter Stephen Patrick1, Yichao Yu1, Bernard Siow1, Mark F Lythgoe1, and Quentin A Pankhurst2

1Centre for Advanced Biomedical Imaging, UCL, London, United Kingdom, 2Davy-Faraday Research laboratories, UCL, London, United Kingdom

Minimally invasive, focal therapies aim to deliver more effective treatment to the patient while reducing off target effects. As such, we have developed MINIMA, a minimally invasive, image-guided ablation MRI technique, whereby a magnetic thermoseed can be manoeuvred through tissue, localised with real time imaging and then heated to cause cell death. We demonstrate submillimetre precision of movement through ex vivo brain tissue and that the seed can be heated via application of radiowaves to cause well defined regions of cell death. These results show that MINIMA is a promising new technique that could help transform MRI into a brand new theranostic device.

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