Abstract #3851

Feasibility and Demonstration of Controlled, Comprehensive Delivery of Clot-busting Drugs for MR Image-Guided Intracerebral Clot Evacuation

Robert Moskwa¹, Miles Olsen¹, Jen Meudt², Robby Weyker², Morgan McCue², Terry Oakes³, Ethan Brodsky¹, Dhanansayan Shanmuganayagam², Azam Ahmed⁴, and Walter Block¹

¹Medical Physics, University of Wisconsin, Madison, WI, United States, ²Animal Sciences, University of Wisconsin, Madison, WI, United States, ³Radiology, University of Wisconsin, Madison, WI, United States, ⁴Neurosurgery, University of Wisconsin, Madison, WI, United States

A recent NIH Trial has shown success in minimizing the effects of intracerebral hemorrhage through insertion of a minimally invasive catheter into the clot through a craniotomy. The catheter then injects 1 ml of clot-busting drugs followed by an 8 hour period of draining the lysed blood. The conservative procedure is repeated for 3-5 days as only very small dosages can be administered due to CT’s inability to directly monitor the drug’s safe distribution. We demonstrate how pressurized infusions can create broader treatments that lyse the clot rapidly while MRI visualizes the drug distributions to maintain safety.

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