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Abstract #3851

Feasibility and Demonstration of Controlled, Comprehensive Delivery of Clot-busting Drugs for MR Image-Guided Intracerebral Clot Evacuation

Robert Moskwa1, Miles Olsen1, Jen Meudt2, Robby Weyker2, Morgan McCue2, Terry Oakes3, Ethan Brodsky1, Dhanansayan Shanmuganayagam2, Azam Ahmed4, and Walter Block1

1Medical Physics, University of Wisconsin, Madison, WI, United States, 2Animal Sciences, University of Wisconsin, Madison, WI, United States, 3Radiology, University of Wisconsin, Madison, WI, United States, 4Neurosurgery, University of Wisconsin, Madison, WI, United States

A recent NIH Trial has shown success in minimizing the effects of intracerebral hemorrhage through insertion of a minimally invasive catheter into the clot through a craniotomy. The catheter then injects 1 ml of clot-busting drugs followed by an 8 hour period of draining the lysed blood. The conservative procedure is repeated for 3-5 days as only very small dosages can be administered due to CT’s inability to directly monitor the drug’s safe distribution. We demonstrate how pressurized infusions can create broader treatments that lyse the clot rapidly while MRI visualizes the drug distributions to maintain safety.

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