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Abstract #3869

Quantitative Assessment of Temporal Changes in fMRI and DTI Parameters in the Squirrel Monkey Spinal Cord after Injury

Arabinda Mishra1, Feng Wang1, Li Min Chen1, and John C Gore1

1Radiology, Vanderbilt University, Nashville, TN, United States

Previous studies have reported changes in resting state functional connectivity between horns in spinal cord following injury. In this work we quantified changes in connectivity and diffusion parameters at identical spinal segments in squirrel monkey cervical spinal cords acquired in concurrent sessions to compare the temporal variations of functional and structural changes during recovery after spinal cord injury (SCI). The degree of axonal disruption and demyelination measured using fractional anisotropy and radial diffusivity at two stages of recovery were compared in various white matter tracts.

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