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Abstract #3884

Disrupted Cerebellar Connectivity with the Central Executive Network and the Default-mode Network in unmedicated Bipolar II Disorder

Xiaomei Luo1,2, Guanmao Chen1, Yanbin Jia3, Jiaying Gong4, Shaojuan Qiu1, Shuming Zhong3, Lianping Zhao5, Feng Chen1, Shunkai Lai3, Zhangzhang Qi⁠1, Long Qian6, Li Huang1, and Ying Wang1

1Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, China, 2Institute of Molecular and Functional Imaging, Jinan University, Guangzhou, China, 3Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou, China, 4Department of Radiology, Six Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, 5Department of Radiology, Gansu Provincial Hospital, Gansu, China, 6GE Healthcare, MR Research China, Beijing, China

The present study aims to investigate the FC between the cerebellum and cerebrum, particularly the central executive network (CEN) and the default-mode network (DMN) in BD II. Seed-based connectivity analyses were performed in 94 unmedicated BD II depression and 100 healthy controls (HCs). Patients with BD II depression showed disrupted FC between the cerebellum and the CEN (mainly in the left dlPFC and ACC) and DMN (mainly in the left mPFC and temporal lobe), suggesting the significant role of the cerebellum-CEN and -DMN connectivity in the pathogenesis of BD.

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