Abstract #3889

Olfactory Network Functional Connectivity with the Hippocampus in Alzheimer’s Disease

Lu Jiaming¹, Nicole Testa¹, Rebecca Jordan¹, Qing Yang¹, Paul Eslinger², and Prasanna Karunanayaka¹

¹Radiology, Penn State University, Hershey, PA, United States, ²Neurology, Penn State University, Hershey, PA, United States

The rhinencephalic brain regions are specifically vulnerable to AD pathology. This suggests that olfactory assessment may be able to serve as a measure of AD progression. In this research, we investigated the functional connectivity (FC) between the olfactory network (ON) and the hippocampus as a sensitive marker to detect progressive AD pathophysiology. The results show that the ON FC is able to differentiate between early mild cognitive impairment (MCI) and late MCI subjects. As such, ON FC may provide critical insights into relationships between olfactory, memory and, other cognitive deficits in AD.

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