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Abstract #3891

Aberrant Functional Connectivity and Network Topology in Parkinson’s Disease Patients with Mild Cognitive Impairment.

Karthik Sreenivasan1, Ece Bayram1, Sarah Banks2, Jason Longhurst1, Zhengshi Yang1, Xiaowei Zhuang1, Dietmar Cordes1, Aaron Ritter1, Jessica Caldwell1, Brent Bluett3, and Virendra Mishra1

1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, 2University of California, San Diego, San Diego, CA, United States, 3Stanford University, Stanford, CA, United States

Studies have shown that cognitive impairment is a frequent non-motor manifestation of Parkinson’s disease (PD), and can already be detected in 15 to 40% of newly-diagnosed PD patients with up to 80% of patients eventually developing dementia. Our results show decreased functional connectivity between regions known to be implicated in high level cognitive functioning in Parkinson’s disease patients with mild cognitive impairment (PD-MCI) , when compared to the cognitively normal PD patients(PD-nMCI). Furthermore, we found altered network topology in PD-MCI compared to the PD-nMCI group that was differentially correlated with neuropsychological measures.

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