Abstract #3891

Aberrant Functional Connectivity and Network Topology in Parkinson’s Disease Patients with Mild Cognitive Impairment.

Karthik Sreenivasan¹, Ece Bayram¹, Sarah Banks², Jason Longhurst¹, Zhengshi Yang¹, Xiaowei Zhuang¹, Dietmar Cordes¹, Aaron Ritter¹, Jessica Caldwell¹, Brent Bluett³, and Virendra Mishra¹

¹Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, ²University of California, San Diego, San Diego, CA, United States, ³Stanford University, Stanford, CA, United States

Studies have shown that cognitive impairment is a frequent non-motor manifestation of Parkinson’s disease (PD), and can already be detected in 15 to 40% of newly-diagnosed PD patients with up to 80% of patients eventually developing dementia. Our results show decreased functional connectivity between regions known to be implicated in high level cognitive functioning in Parkinson’s disease patients with mild cognitive impairment (PD-MCI) , when compared to the cognitively normal PD patients(PD-nMCI). Furthermore, we found altered network topology in PD-MCI compared to the PD-nMCI group that was differentially correlated with neuropsychological measures.

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