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Abstract #3897

Peculiarities of brain activation during dominant hand tactile perception in lateralized Parkinson disease

Oleksii Omelchenko1

1Anatomy and Physiology, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine

Parkinson's disease (PD) in mostly presented with asymmetrical motor symptoms. Disturbed sensorimotor integration and decrease of somatosensory cortex activation was previously shown. We analyzed brain activation and connectivity during the unilateral tactile stimulation in primary and non-primary hand lateralized PD patients. We have demonstrated steady contralateral S1 activation in PD. Primary hand tactile stimulation in primary hand lateralized PD patients evokes activation of primary and associative sensory, motor and executive nodes of the cortex. Mirror neuron system was activated in primary hand stimulation in PD patients. Tactile stimuli processing evokes increased connectivity of globus pallidus, premotor, prefrontal and parietal cortex.

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