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Abstract #3911

Combination of Primary and Temporal Derivative Estimates in Functional MRI

Kwan-Jin Jung1

1Human MR Center, University of Massachusetts Amherst, Amherst, MA, United States

In the general linear model analysis of a task fMRI, the response latency was analyzed by including a derivative parameter estimate of the hemodynamic response function. The existing method of combining the two estimates was improved to provide a more appropriate sign and amplitude of the combined estimate, which was presented in 2018 ISMRM. The last year’s method has been further improved to determine the sign of the combined estimate using a coordinate transformation method and to regulate the variance of the combined estimate by introducing an ellipse model. The new WSA method was experimentally confirmed using the HCP database.

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