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Abstract #3916

Improvement of functional sensitivity using multi-echo EPI and BOLD response based HRF model at 7T

Uksu Choi1,2, Toshiko Tanaka1,2, Masahiko Haruno1,2, and Ikuhiro Kida1,2

1Center for Information and Neural Networks, National Institute of Information and Communications Technology, Suita, Japan, 2Graduate School of Frontier Biosciences, Osaka University, Suita, Japan

To study amygdala function, we used multi-echo EPI sequence as fMRI at 7T to reduce the effects of local magnetic field inhomogeneity in the region. Additionally, to increase sensitivity, we modified a hemodynamic response function model from an empirical model. These methods allowed us to detect robust activation of the amygdala and brain areas related to emotional face discrimination tasks in addition to increased functional connectivity between them. Using an appropriate acquisition method and statistical model can improve sensitivity in regions whose signal is suffered by local magnetic field inhomogeneity in ultra-high field fMRI studies.

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