The resting state fMRI (rfMRI) was used to estimate the BOLD signal change in response to natural breathing to measure the impairment of cerebra vascular reactivity (CVR) due to the presence of tumor. CVR associated values were obtained from the low frequency fluctuation of rfMRI and averaged over whole brain and tumor region of interests to measure the frequency related CVR properties respectively. These results indicate the existence of inter/intrasubject variability in low frequency and more sensitivity of the whole brain homogeneity to frequency rather than tumor. CVR mapping can determine the area of potential neuro-vascular uncoupling in the brain.
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