Abstract #3928

Real-time fMRI amygdala neurofeedback training reduces depression symptoms and appears to normalize amygdala and hippocampal volumes

Beni Mulyana^1,2, Masaya Misaki¹, Kymberly D Young^1,3, Vadim Zotev¹, Jennifer Stewart¹, Samuel Cheng², and Jerzy Bodurka^1,4

¹Laureate Institute for Brain Research, Tulsa, OK, United States, ²Electrical and Computer Engineering, University of Oklahoma, Tulsa, OK, United States, ³Department of Psychiatry, University of Pittsburg, Pittsburg, PA, United States, ⁴Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, United States

We evaluated structural brain changes as a result of real-time fMRI neurofeedback (rtfMRI-nf) left amygdala training in major depressive disorder (MDD). Unmedicated MDD patients completed an active (n=33) or control (neurofeedback from intraparietal sulcus; n=29) rtfMRI-nf training session with structural magnetic resonance imaging scans. Volume decreases of the hippocampus HATA subregion and cortical nucleus of the amygdala were linked to MDD symptom decrease as a function of training. Individual differences in HATA and cortical nucleus pre-treatment volumes impacted the degree of volume change in both active and control groups and could be a moderating factor of volume normalization.

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