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Abstract #3934

Sub-Millimeter Resolution Compressed Sensing GRASE for T2-Weighted Functional MRI at 7 Tesla

Suhyung Park1, Alexander Beckett1, and David Feinberg1,2

1University of California, Berkeley, Berkeley, CA, United States, 2Advanced MRI Technologies, Sebastopol, CA, United States

At high magnetic field, 7T and above, T2-weighted fMRI has drawn attention for its high specificity in columnar and layer specific fMRI by minimizing draining vein effects compared to T2*-weighted GE-EPI based fMRI. 3D inner-volume gradient and spin echo (3D-GRASE) has been proposed and used for sub-millimeter resolution. However, reduced field-of-view (FOV) imaging in general has disadvantages compared to GE-EPI: 1) small FOV, 2) T2 induced blurring, both along the partition direction, and 3) low signal-to-noise ratio (SNR) from long TE with EPI readouts. To address both issues, 3D GRASE is extended to volumetric ky-kz random undersampling followed by performing CS for signal recovery (3D CS-GRASE). The ky-kz undersampling extends volume coverage without compromising the blurring while enhancing SNR due to short TE from inplane undersampling.

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