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Abstract #3946

Comparison of continuous sampling with active noise cancellation and sparse sampling for cortical and subcortical auditory fMRI

Rebecca Susan Dewey1,2,3, Deborah A Hall2,3,4, Christopher J Plack5,6,7, and Susan T Francis1

1Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, 2NIHR Nottingham Biomedical Research Centre, Nottingham, United Kingdom, 3Hearing Sciences, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United Kingdom, 4University of Nottingham Malaysia, Jalan Broga, Selangor Darul Ehsan, Malaysia, 5Manchester Centre for Audiology and Deafness (ManCAD), University of Manchester, Manchester, United Kingdom, 6NIHR Manchester Biomedical Research Centre, Manchester, United Kingdom, 7Department of Psychology, Lancaster University, Lancaster, United Kingdom

We compared cortical and subcortical auditory BOLD fMRI responses to epochs of broadband noise acquired using continuous sampling with active noise cancellation (TR = 2s) to sparse sampling (TR = 8s, 1993ms acquisition with 6007ms silence) in a repeated measures factorial design. High resolution (1.5 mm3) 3 Tesla fMRI data were acquired using multiband 2 and corrected for physiological noise and image distortions. BOLD beta estimates are compared for onset, offset and sustained auditory fMRI responses for both sampling schemes. We report the strengths and weaknesses of the two sampling methods.

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