Abstract #3955

Multi-Excitation MRE in Aging Human Brain: Estimation of Direction-Dependent Mechanical Properties

Nicolas R Gallo¹, Stacey M Cahoon¹, Aaron A Anderson², Assimina A Pelegri³, and John G Georgiadis^1,2

¹Biomedical Engineering Department, Illinois Institute of Technology, Chicago, IL, United States, ²Beckman Institute, University of Illinois at Urbana-Champaign, Champaign, IL, United States, ³Department of Mechanical & Aerospace Engineering, Rutgers University, Piscataway, NJ, United States

Healthy aging affects the local mechanical properties of the human brain tissue but their estimation remains a challenge, especially in strongly anisotropic white matter regions. This study merges previous MRE aging research involving high-resolution, full-coverage, and multi-excitation MRE imaging with the ability to estimate anisotropic shear moduli locally. We identified important anisotropic differences in the storage modulus in the corpus callosum, which help differentiate old from the young.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.