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Abstract #3957

In vivo Assessment of Gray Matter Stiffness and Perfusion in the Human Brain

Siri Fløgstad Svensson1, Grethe Løvland2, Wibeke Nordhøy1, Ralph Sinkus3,4, Omar Darwish3, José Rodrigues De Arcos3, and Kyrre Eeg Emblem1

1Department for Diagnostic Physics, Oslo University Hospital, Oslo, Norway, 2The Intervention Center, Oslo University Hospital, Oslo, Norway, 3Division of Imaging Sciences & Biomedical Engineering, King's College London, London, United Kingdom, 4Inserm U1148, LVTS, University Paris Diderot, Paris, France

MR Elastography (MRE) is an emerging imaging technique used to quantify the stiffness and viscosity of tissue. Few studies have investigated the relationship between these biomechanical properties and brain perfusion. If understood, this could provide valuable new insight in diseases that alter biomechanical properties or functionality. In our study we assess the cerebral blood flow and the tissue stiffness of gray matter in healthy volunteers. We find that in cortical gray matter, both the cerebral blood flow and the shear storage modulus G’ was higher than in deep gray matter.

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