Although MR elastography (MRE) is a preferred diagnostic tool for hepatic fibrosis, MRE-derived mechanical properties are affected by factors such as portal pressure. Since portal pressure is modulated across the breathing cycle, we sought to evaluate the effect of breathing condition by acquiring MRE in end expiration and end inspiration in 19 healthy volunteers. A gravitational transducer operating at 50Hz was used, which yielded a satisfactory repeatability. Storage modulus values were significantly higher at end inspiration than at end expiration, and the amplitude of the difference was significantly correlated to the end inspiration storage modulus values.
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