Spin-lock technologies are useful for probing macromolecular environment of tissue. The conventional spin-lock approaches cannot lock water and fat spins simultaneously due to chemical shift effect of fat, which can lead to artifacts in tissues with fatty infiltration. Based on the latest development of the spin-lock technique, we propose spin-lock Dixon methods to perform water-fat separation in spin-lock MRI. Our methods may offer a solution to perform reliable spin-lock MRI in tissues with fatty infiltration.
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