Abstract #4027

MRI Susceptibility Mapping Shows Decreased Venous Oxygen Saturation in Sickle Cell Anaemia

Russell Murdoch¹, Hanne Stotesbury², Jamie Kawadler², Fenella Kirkham², and Karin Shmueli¹

¹Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ²Developmental Neurosciences, UCL Great Ormond Street Hospital Institute of Child Health, London, United Kingdom

Ischemic stroke is a common and severe occurrence in Sickle Cell Anaemia (SCA) but no accurate screening measures currently exist for adults. Changes in venous oxygen saturation (Y_v) have been suggested as a potential biomarker but measuring Y_v in vivo is challenging. This work explores the potential of MRI susceptibility mapping to measure Y_v in SCA subjects. Susceptibility-mapping-based measures of Y_v were compared between 25 SCA subjects and 15 healthy controls. Significantly lower Y_v was measured in the superior sagittal sinus in the SCA group compared to healthy controls, showing that QSM is sensitive to changes in Y_v in SCA.

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