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Abstract #4032

Comparison of Stretched-Exponential, IVIM and Monoexponential Diffusion-Weighted Imaging Mathematical Models for Assessment of Tumor Aggressiveness in Prostate Cancer at 3T

Tsutomu Tamada1, Ayumu Kido1, Hidemitsu Sotozono1, Akihiko Kanki1, Akira Yamamoto1, and Yu Ueda2

1Kawasaki Medical School, Kurashiki City, Japan, 2Philips Electronics Japan, Osaka, Japan

We compared monoexponential and non-Gaussian models including intravoxel incoherent motion imaging (IVIM) and stretched-exponential model in diffusion-weighted imaging (DWI) for characterization of prostate cancer. ADCmean in monoexponential model, D in IVIM, and DDC in stretched model showed high discrimination ability with AUC>0.80 between GS=3+3 and GS≥3+4 tumors as well as GS≤3 + 4 and GS≥4 + 3 tumors, but no significant difference among these metrics. Our study did not show a clear clinical value of non-Gaussian models including IVIM and stretched model compared with standard monoexponential model for assessment of tumor aggressiveness in prostate cancer.

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