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Abstract #4052

Exploring analytical models of the diffusion MR signal in non-pregnant cervical tissue in 3T

Elisenda Bonet-Carne1, Jana Hutter2, Paddy J Slator1, Lucilio Cordero-Grande2, Daniel C Alexander1, Andrew H. Shennan3, Mary A. Rutherford2, Eleftheria Panagiotaki1, and Lisa Story2,3

1Centre for Medical Image Computing, University College London, London, United Kingdom, 2Centre for the Developing Brain, King’s College London, London, United Kingdom, 3Division of Women’s Health, King’s College London, London, United Kingdom

Preterm Birth is a major healthcare problem and its appropriate prediction remains a challenge. Extensive research utilising advanced MR protocols has been undertaken on the cervical malignancy, but cervical structure and remodelling in term and preterm pregnancies is little studied. As part of a larger project, this work aims to explore model-based diffusion MRI microstructural models along the non-pregnant cervix. We compare multi-compartment microstructure models to analyse the diffusion signal. Initial results reveal that more complex models than the Apparent Diffusion Coefficient are required to characterise the cervical tissue microstructure.

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