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Abstract #4062

Model-Driven Registration for 3D Placental Diffusion-Weighted MRI

Dimitra Flouri1,2, Rosalind Aughwane3, Magdalena Sokolska4, Nada Mufti 1,3, David Atkinson5, Giles Kendall3, Alan Bainbridge4, Tom Vercauteren1,2, Sebastien Ourselin1, Anna L David3,6,7, and Andrew Melbourne1,2

1School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom, 2Department of Medical Physics & Biomedical Engineering, University College London, University College London, London, United Kingdom, 3Institute for Women’s Health, University College London, London, United Kingdom, 4Medical Physics, University College London Hospital, London, United Kingdom, 5Centre for Medical Imaging, University College London, London, United Kingdom, 6University Hospital KU Leuven, Leuven, Belgium, 7NIHR University College London Hospitals Biomedical Research Centre, London, United Kingdom

The placenta is essential for successful pregnancy outcome. Placental imaging is however challenging due to maternal breathing motion and fetal movements, making motion correction important for subsequent analysis. This study introduces an iterative model-based registration technique which incorporates a joint placenta-specific signal model for diffusion and relaxation data into the motion correction process. We compared our method to a pre-existing method used for contrast-enhanced data making use of principal component analysis. Our results suggest that the proposed method significantly improves alignment of free-breathing placenta relaxation and DW-MRI data and evidence that the precision of markers of function obtained in placenta can be improved.

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