Abstract #4076

Novel Nanoparticle-enhanced T1-Mapping Enables Estimation of Placental Fractional Blood Volume in a Pregnant Mouse Model

Andrew A Badachhape^1,2, Laxman Devkota¹, Igor Stupin², Mayank Srivastava², Prajwal Bhandari¹, Poonam Sarkar³, Ketan B Ghaghada^1,2, Eric A Tanifum^1,2, and Ananth V Annapragada^1,2

¹Radiology, Baylor College of Medicine, Houston, TX, United States, ²Pediatric Radiology, Texas Children's Hospital, Houston, TX, United States, ³Pediatric Oncology, Baylor College of Medicine, Houston, TX, United States

Greater than 60% of placentae from low birth weight infants show signs of hypoxic or ischemic injury from vascular hypo-perfusion. Placental fractional blood volume (FBV) is indicative of perfusion and may be used as a marker of local ischemia. Non-invasive methods for the estimation of placental FBV are therefore of interest in the study of placental pathology. In this pre-clinical study, we investigated contrast-enhanced magnetic resonance imaging (MRI) for the estimation of placental FBV in a pregnant mouse model. A high T1 relaxivity blood-pool liposomal-gadolinium (liposomal-Gd) contrast agent, which does not permeate placental barrier in rodents, was used to calculate placental FBV.

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