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Abstract #4076

Novel Nanoparticle-enhanced T1-Mapping Enables Estimation of Placental Fractional Blood Volume in a Pregnant Mouse Model

Andrew A Badachhape1,2, Laxman Devkota1, Igor Stupin2, Mayank Srivastava2, Prajwal Bhandari1, Poonam Sarkar3, Ketan B Ghaghada1,2, Eric A Tanifum1,2, and Ananth V Annapragada1,2

1Radiology, Baylor College of Medicine, Houston, TX, United States, 2Pediatric Radiology, Texas Children's Hospital, Houston, TX, United States, 3Pediatric Oncology, Baylor College of Medicine, Houston, TX, United States

Greater than 60% of placentae from low birth weight infants show signs of hypoxic or ischemic injury from vascular hypo-perfusion. Placental fractional blood volume (FBV) is indicative of perfusion and may be used as a marker of local ischemia. Non-invasive methods for the estimation of placental FBV are therefore of interest in the study of placental pathology. In this pre-clinical study, we investigated contrast-enhanced magnetic resonance imaging (MRI) for the estimation of placental FBV in a pregnant mouse model. A high T1 relaxivity blood-pool liposomal-gadolinium (liposomal-Gd) contrast agent, which does not permeate placental barrier in rodents, was used to calculate placental FBV.

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