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Abstract #4104

Quantitative assessment of changes in breast background parenchymal enhancement following tamoxifen treatment

Milica Medved1, Keiko Tsuchiya2, Gregory S Karczmar1, and Hiroyuki Abe1

1Radiology, The University of Chicago, Chicago, IL, United States, 2Radiology, Shiga University of Medical Science, Otsu, Japan

Our study introduces a standardizing model of background parenchymal enhancement (BPE) in DCEMRI sequences that can be used to quantitatively and objectively describe changes in BPE rates following preventative tamoxifen treatment. This is in contrast with the current practice of using 4 subjective categories to describe BPE. Decreased BPE rates post-treatment agree with earlier results showing that BPE, like breast density, correlates with breast cancer risk. Standardization for imaging parameters and contrast agent relaxivity increases the observed effect size, giving evidence of increased sensitivity to treatment-induced changes and the potential as a tool for individual breast cancer risk management.

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