Abstract #4115

Radiomic Analysis of Breast Cancer Peritumoral Tissue on Contrast Enhanced MRI Prior to Neoadjuvant Chemotherapy

Eva Gombos¹, Carlos Aramayo², and Jayender Jagadeesan³

¹Radiology, Brigham and Women's Hospital, Boston, MA, United States, ²Geisel School of Medicine at Dartmouth, Hanover, NH, United States, ³Surgical Planning Laboratory, Brigham and Women's Hospital, Boston, MA, United States

This study set out to identify key radiomic features in peritumoral breast tissue associated with a high response to neoadjuvant chemotherapy, defined as a >90% reduction of tumor cells. For each case, a tumor label map and 5 distinct masks at 2.5, 5, 10, 15, and 20mm beyond the tumor border were created using pretreatment DCE-MRIs. Fifty-seven metrics were then computed for each mask using the 3D Slicer HeterogeneityCAD module. Using final pathology reports, cases were separated into “low-response” and “high-response” groups. Statistical correlation using univariate Mann-Whitney tests to compare the two response groups ultimately yielded 6 radiomic features.

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