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Abstract #4121

A comparative study of multi-shot diffusion-weighted imaging (DWI) using multiplexed sensitivity encoding (MUSE) and conventional single-shot echo-planar imaging (EPI) DWI in breast cancer

Gabrielle C. Baxter1, Ramona Woitek1, Amy J. Frary1, Gavin C. Houston2, Martin J. Graves3, Fiona J. Gilbert1, and Andrew J. Patterson3

1Department of Radiology, University of Cambridge, Cambridge, United Kingdom, 2Global Research Organisation, GE Healthcare, Buckinghamshire, United Kingdom, 3Department of Radiology, Addenbrooke's Hospital, Cambridge, United Kingdom

MUSE (multiplexed sensitivity encoding) is a multi-shot echo-planar imaging (EPI) technique used in diffusion-weighted imaging (DWI) that reduces distortion and blurring compared to single-shot EPI. Experiments using a breast phantom aimed to investigate the effect of varying parallel acceleration and number of shots on geometric distortion and quantification of the apparent diffusion coefficient (ADC). A refined protocol was applied to a small cohort of patients to comparatively assess improvements in image quality.

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