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Abstract #4144

The Impact of Echo-time on Hyperpolarized Xenon-129 CSSR Measurements

Faraz Amzajerdian1, Kai Ruppert1, Yi Xin1, Hooman Hamedani1, Luis Loza1, Tahmina Achekzai1, Ryan J. Baron1, Ian F. Duncan1, Harrilla Profka1, Sarmad Siddiqui1, Mehrdad Pourfathi1, Federico Sertic1, Maurizio F. Cereda2, and Rahim R. Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, United States

Chemical Shift Saturation Recovery (CSSR) MR spectroscopy and imaging are powerful techniques for deriving a number of important physiological pulmonary parameters. We investigated the impact of measurement echo time on the spectral composition of the acquisition and the subsequent numerical data analysis in rabbits. We found that lengthening the TE resulted in a vastly improved separation between the dissolved-phase resonances by suppressing short T2* signal components. As consequence of this phenomenon, the measured septal wall thickness changed with TE by 1.0 ± 0.13 μm/ms. Similarly, we hypothesize that CSSR-derived measures of pulmonary physiology might be field strength-dependent.

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