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Abstract #4146

A Technique for Measuring Long-Term Alterations in Pulmonary Gas Uptake under Free-Breathing in a Murine Model of Radiation-Induced Lung Injury

Luis A Loza1, Stephen Kadlecek1, Mehrdad Pourfathi1, Tahmina Achekzai1, Kai Ruppert1, Ian Duncan1, and Rahim R. Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States

Computed tomography (CT), pulmonary function tests (PFT) and positron-emission tomography (PET) are all currently used to assess lung structure and function clinically. However, the sensitivity and safety of these modalities limit their use in cases of progressive lung disease, where longitudinal measurements are of value for both therapeutic planning and monitoring response to treatment. Hyperpolarized 129Xe (HXe) MRI provides robust, specific information about the lungs and is suitable for longitudinal measurements. In this study, we demonstrate an HXe MRI technique for detecting and assessing alterations in pulmonary gas uptake in a mouse model of RILI under spontaneous respiration.

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