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Abstract #4199

Neurostimulation Safety Investigations using Reference, Posable Anatomical Models

Antonino Mario Cassara'1, Bryn Lloyd1, Silvia Farcito1, Esra Neufeld1, Gisela Hagberg2, and Niels Kuster1,3

1Foundation for Information Technology in Society, Zurich, Switzerland, 2Max Plank Institute, Tuebingen, Germany, 3Swiss Federal Institute of Technology (ETHZ), Zurich, Switzerland

Investigations about the risk of Peripheral Nerve Stimulation (PNS) in magnetic resonance imaging (MRI) are fundamental to mitigate potential safety issues related to the new generation of MRI scanners that use larger Larmor fields and faster/higher gradients. In this study we evaluate the potential of in silico studies for determining the thresholds of PNS when taking into account the anatomical detail and electrophysiology of the peripheral nervous system. We used the latest hybrid electromagnetic (EM) and neuronal simulators combined with our recently released neuro-functionalized Virtual Population model Yoon-sun V4.0. The vision is to utilize such systems for pulse sequence optimization to reduce PNS, the revision of low frequency exposure guidelines, etc..

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