Investigations about the risk of Peripheral Nerve Stimulation (PNS) in magnetic resonance imaging (MRI) are fundamental to mitigate potential safety issues related to the new generation of MRI scanners that use larger Larmor fields and faster/higher gradients. In this study we evaluate the potential of in silico studies for determining the thresholds of PNS when taking into account the anatomical detail and electrophysiology of the peripheral nervous system. We used the latest hybrid electromagnetic (EM) and neuronal simulators combined with our recently released neuro-functionalized Virtual Population model Yoon-sun V4.0. The vision is to utilize such systems for pulse sequence optimization to reduce PNS, the revision of low frequency exposure guidelines, etc..
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