Abstract #4238

Detection of metabolite concentration changes in young adult volunteer brains after oral glucose administration using short-TE STEAM 1H MRS sequence at 7T

Hideto Kuribayashi¹, Nouha Salibi², Ravi Teja Seethamraju³, Sinyeob Ahn⁴, Koji Fujimoto⁵, Tadashi Isa⁵, and Tomohisa Okada⁵

¹Siemens Healthineers, Tokyo, Japan, ²Siemens Healthineers, Malvern, PA, United States, ³Siemens Healthineers, Boston, MA, United States, ⁴Siemens Healthineers, San Francisco, CA, United States, ⁵Human Brain Research Center, Kyoto Univeristy, Kyoto, Japan

Glucose detection was examined in young adult volunteer brains (the posterior cingulate cortex) with ¹H downfield MRS at 7T, and metabolite concentration changes before and c.a. 55 minutes after oral 50-g glucose administration were measured with the downfield and a conventional upfield MRS. The downfield MRS detected H1-α-glucose peak at 5.3 ppm and quantified glucose concentration as a wider range compared to that with the upfield MRS using LCModel. Detection of the H1-α-glucose peak showed a potential to quantify net glucose concentration without underestimation.

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