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Abstract #4238

Detection of metabolite concentration changes in young adult volunteer brains after oral glucose administration using short-TE STEAM 1H MRS sequence at 7T

Hideto Kuribayashi1, Nouha Salibi2, Ravi Teja Seethamraju3, Sinyeob Ahn4, Koji Fujimoto5, Tadashi Isa5, and Tomohisa Okada5

1Siemens Healthineers, Tokyo, Japan, 2Siemens Healthineers, Malvern, PA, United States, 3Siemens Healthineers, Boston, MA, United States, 4Siemens Healthineers, San Francisco, CA, United States, 5Human Brain Research Center, Kyoto Univeristy, Kyoto, Japan

Glucose detection was examined in young adult volunteer brains (the posterior cingulate cortex) with 1H downfield MRS at 7T, and metabolite concentration changes before and c.a. 55 minutes after oral 50-g glucose administration were measured with the downfield and a conventional upfield MRS. The downfield MRS detected H1-α-glucose peak at 5.3 ppm and quantified glucose concentration as a wider range compared to that with the upfield MRS using LCModel. Detection of the H1-α-glucose peak showed a potential to quantify net glucose concentration without underestimation.

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