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Abstract #4247

Pointwise T2 fitting for spectral relaxography: examples in dystrophic and healthy muscle

Eric Baetscher1, William Triplett2, Glenn Walter2, and William Rooney1

1Advanced Imaging Research Center, Oregon Health and Science University, Portland, OR, United States, 2University of Florida, Gainesville, FL, United States

We present a model-free approach for frequency domain transverse relaxation time (T2) analysis and post-processing. Multiple echo-time (TE) magnetic resonance spectroscopy (MRS) data is fit for M0 and T2 at each point in the frequency spectrum to produce derived plots of T2 as a function of chemical shift. T2 values of certain in-vivo resonances are in good agreement with prior literature. The spectral T2 (sT2) obtained by pointwise fitting and plotting shows remarkably defined features. Results are shown for spectra obtained from normal leg muscle and muscle in subjects with Duchenne Muscular Dystrophy (DMD).

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