Abstract #4263

Macrocyclic Manganese (II) Complex of Mefenamic acid (MA) Conjugate as an Inflammation Targeting MRI Contrast Agent

Md Kamrul Islam¹, Hee-Kyung Kim^2,3, Soyeon Kim¹, Bo Kyung Sung¹, Garam Choi¹, Ah Rum Baek¹, Sunghwan Hwang¹, Byeong Woo Yang¹, Heejin Seo¹, Hoesu Jung⁴, Taekwan Lee⁴, and Yongmin Chang⁵

¹Medical and Biological Engineering, Kyungpook National University, Daegu, Korea, Republic of, ²Molecular Medicine, Kyungpook National University, Daegu, Korea, Republic of, ³3Institute of Biomedical Engineering Research, Kyungpook National University, Daegu, Korea, Republic of, ⁴Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Korea, Republic of, ⁵Radiology, Kyungpook National University, Daegu, Korea, Republic of

The purpose of the present study is to design and synthesis of novel macrocyclic Mn²⁺ complex as an alternative to the well-established Gd³⁺ based chelates for use as an inflammation targeting MR imaging agent. This new complex exhibits higher r1 relaxivity (2.32 mM⁻¹ s⁻¹) than clinically approved Mn-DPDP® (1.6 mM⁻¹ s⁻¹) at 4.7 T. T₁-weighted MR coronal images display strong signal enhancement in liver, heart, gallbladder and kidney. In an inflammatory mouse model, it shows greater inflammatory tissues detection with in a clinical dose.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.