Abstract #4269

Dysprosium complexes encapsulated apoferritin T2 MRI contrast agent for ultra-high field MRI

Hee-Kyung Kim^1,2, Ahrum Baek³, Sunghwan Hwang³, Soyeon Kim³, Garam Choi³, Bo Kyung Sung³, Byeong Woo Yang³, Heejin Seo³, MD. Kamrul Islam³, Hoesu Jung⁴, Taekwan Lee⁴, and Yongmin Chang⁵

¹Department of Molecular Medicine & BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu, Korea, Republic of, ²Institute of Biomedical Engineering Research, Daegu, Korea, Republic of, ³Department of Medical &Biological Engineering, Kyungpook National University, Daegu, Korea, Republic of, ⁴Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Korea, Republic of, ⁵Department of Radiology, Kyungpook National University, Daegu, Korea, Republic of

Apo[Dy(DO3A-ph-NH₂)] is synthesized according to the precede literature. The absorbance is changed at 300-400 nm after encapsulation of Dy(DO3A-ph-NH₂), and we confirmed the morphology of Dy(DO3A-ph-NH₂) encapsulated protein with TEM image. The final concentration of paramagnetic composition is calculated by ICP. The relaxivities of Dy(DO3A-ph-NH₂) encapsulated protein at various external fields (3 - 15.2 T) are considerably increased, and also r₂/r₁ ratios are increased up to 55 at 15.2 T.

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