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Abstract #4269

Dysprosium complexes encapsulated apoferritin T2 MRI contrast agent for ultra-high field MRI

Hee-Kyung Kim1,2, Ahrum Baek3, Sunghwan Hwang3, Soyeon Kim3, Garam Choi3, Bo Kyung Sung3, Byeong Woo Yang3, Heejin Seo3, MD. Kamrul Islam3, Hoesu Jung4, Taekwan Lee4, and Yongmin Chang5

1Department of Molecular Medicine & BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu, Korea, Republic of, 2Institute of Biomedical Engineering Research, Daegu, Korea, Republic of, 3Department of Medical &Biological Engineering, Kyungpook National University, Daegu, Korea, Republic of, 4Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Korea, Republic of, 5Department of Radiology, Kyungpook National University, Daegu, Korea, Republic of

Apo[Dy(DO3A-ph-NH2)] is synthesized according to the precede literature. The absorbance is changed at 300-400 nm after encapsulation of Dy(DO3A-ph-NH2), and we confirmed the morphology of Dy(DO3A-ph-NH2) encapsulated protein with TEM image. The final concentration of paramagnetic composition is calculated by ICP. The relaxivities of Dy(DO3A-ph-NH2) encapsulated protein at various external fields (3 - 15.2 T) are considerably increased, and also r2/r1 ratios are increased up to 55 at 15.2 T.

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