Hyperpolarized (HP) 13C MRI is very appealing due to its potential in imaging the dynamic metabolic conversion and transport process. In this work, we tried to model the cellular transport process for dynamic HP 13C studies. Two highlights in this work are, (1) separating intra- and extracellular HP [1-13C] lactate based on dynamic HP 13C diffusion weighted imaging (DWI) technique, (2) extending standard kpl model to quantify cellular transport, with applications to cancer cell studies and cancer mouse studies.
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