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Abstract #4314

Hyperpolarized 13C MRI Cellular Transport Modeling

Zijun Cui1,2, Xucheng Zhu2, Renuka Sriram2, Zhen Jane Wang2, and Peder EZ Larson2

1School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 2Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States

Hyperpolarized (HP) 13C MRI is very appealing due to its potential in imaging the dynamic metabolic conversion and transport process. In this work, we tried to model the cellular transport process for dynamic HP 13C studies. Two highlights in this work are, (1) separating intra- and extracellular HP [1-13C] lactate based on dynamic HP 13C diffusion weighted imaging (DWI) technique, (2) extending standard kpl model to quantify cellular transport, with applications to cancer cell studies and cancer mouse studies.

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