Abstract #4316

Investigating the Impact of Hypoxia on Lung Metabolism using Hyperpolarized Carbon-13 MRSI

Mehrdad Pourfathi¹, Maurizio Cereda², Yi Xin¹, Stephen Kadlecek¹, Hooman Hamedania¹, Ian Duncan¹, Sarmad Siddiqui¹, Harrilla Profka¹, Kai Ruppert¹, Luis Loza¹, Faraz Amzajerdian¹, Ryan Baron¹, Tahmina Achekzai¹, Federico Sertic¹, Francisca Bermudez¹, and Rahim R. Rizi¹

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, United States

Systemic hypoxemia is a clinical hallmark of many lung pathologies, yet its impact on lung metabolism is not well understood. In this hyperpolarized carbon-13 MRI study, we seek to demonstrate the impact of both moderate and severe systemic hypoxemia on lung pyruvate metabolism using an imaging approach.

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