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Abstract #4316

Investigating the Impact of Hypoxia on Lung Metabolism using Hyperpolarized Carbon-13 MRSI

Mehrdad Pourfathi1, Maurizio Cereda2, Yi Xin1, Stephen Kadlecek1, Hooman Hamedania1, Ian Duncan1, Sarmad Siddiqui1, Harrilla Profka1, Kai Ruppert1, Luis Loza1, Faraz Amzajerdian1, Ryan Baron1, Tahmina Achekzai1, Federico Sertic1, Francisca Bermudez1, and Rahim R. Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, United States

Systemic hypoxemia is a clinical hallmark of many lung pathologies, yet its impact on lung metabolism is not well understood. In this hyperpolarized carbon-13 MRI study, we seek to demonstrate the impact of both moderate and severe systemic hypoxemia on lung pyruvate metabolism using an imaging approach.

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