Currently available non-invasive imaging technologies,
including CT, MRI and ultrasonography, are only able to assess fat accumulation
in the liver. Therefore, these methods are not suitable for a precise diagnosis
of NASH. The standard technique for diagnosing NASH, liver biopsy, has several
drawbacks, such as the higher risk of complications that accompanies invasive
procedures. Here, we demonstrated that in
vivo mitochondrial redox metabolism was dramatically altered at an early
stage, and NASH could be accurately diagnosed by in vivo dynamic nuclear polarization-magnetic resonance imaging, with
carbamoyl-PROXYL as a molecular imaging probe. In addition, this technique was
feasible for distinguishing between NAFLD and NASH. Our data reveal a novel
method for monitoring the dynamics of redox metabolic changes and assessing the
efficacy of therapeutic agents in NAFLD/NASH.
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