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Abstract #4330

Dose minimization in the detection of supraclavicular brown adipose tissue in 18F-FDG TOF-PET/MR: a simulation study

Edwin E.G.W. ter Voert1,2, Julian Müller1, Anton S. Becker3,4, Balaz Miroslav4, Vissarion Efthymiou4, Claudia Irene Maushart5,6, Gani Gashi5,6, Christian Wolfrum4, Matthias J. Betz5,6, and Irene A. Burger1

1Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland, 2University of Zurich, Zurich, Switzerland, 3Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland, 4Department of Health Sciences and Technology, Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland, 5Department of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland, 6University of Basel, Basel, Switzerland

An increasing number of prospective trials are investigating the activity of brown adipose tissue (BAT) with 18F-FDG PET, in patients as well as in healthy volunteers. According to the Brown Adipose Reporting Criteria in Imaging Studies (BARCIST 1.0) the injected dose of 18F-FDG should be as low as possible, for statistically valid imaging, with consideration for total dosage in repeat studies. In our 18F-FDG TOF PET/MR simulation study we found that a minimum injected dose of 15MBq (0.29mSv) still allowed for accurate quantification of BAT activity, without a significant increase in noise or artifacts.

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