Abstract #4330

Dose minimization in the detection of supraclavicular brown adipose tissue in 18F-FDG TOF-PET/MR: a simulation study

Edwin E.G.W. ter Voert^1,2, Julian Müller¹, Anton S. Becker^3,4, Balaz Miroslav⁴, Vissarion Efthymiou⁴, Claudia Irene Maushart^5,6, Gani Gashi^5,6, Christian Wolfrum⁴, Matthias J. Betz^5,6, and Irene A. Burger¹

¹Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland, ²University of Zurich, Zurich, Switzerland, ³Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland, ⁴Department of Health Sciences and Technology, Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland, ⁵Department of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland, ⁶University of Basel, Basel, Switzerland

An increasing number of prospective trials are investigating the activity of brown adipose tissue (BAT) with 18F-FDG PET, in patients as well as in healthy volunteers. According to the Brown Adipose Reporting Criteria in Imaging Studies (BARCIST 1.0) the injected dose of 18F-FDG should be as low as possible, for statistically valid imaging, with consideration for total dosage in repeat studies. In our 18F-FDG TOF PET/MR simulation study we found that a minimum injected dose of 15MBq (0.29mSv) still allowed for accurate quantification of BAT activity, without a significant increase in noise or artifacts.

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